Scientific Overview
Stress and Stress Tolerance
HPA Axis
Circadian Rhythms
Immune System
Placebo Effect
Chronic Fatigue Syndrome
Psychiatric vs Organic Debate
Irritable Bowel Syndrome
Chronic Lyme Disease
Search Site

Information and research into chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), stress, burnout, the HPA axis, the placebo effect and the relationship between mental attitude, lifestyle and physical health.

"All in all, I am very impressed with it and rather enjoyed reading it...I think it is great tool for patient education." - Peter DeMauro, M.D., Hackensack University Medical Center
"You have written a clear and well argued article" - Dr. Fiona Godlee, Editor in chief, The BMJ

Based on the latest research into areas such as the placebo effect and the HPA axis, this website presents information showing how the mind interacts with the immune system and the body's hormone rhythms via the HPA axis to influence health, vitality and stress tolerance. This site also presents the first-ever cohesive theory to explain burnout, chronic fatigue syndrome (CFS, also known as Myalgic Encephalomyelitis or ME), irritable bowel syndrome (IBS), post-viral fatigue syndrome (PVFS) and other misunderstood illnesses, explaining why these illnesses occur and how they can be treated.

Many illnesses such as CFS/ME, IBS and burnout are associated with a dysregulated HPA axis, the body's stress tolerance and energy regulation system. As the HPA axis also regulates the immune system, an imbalance can result in a susceptibility to many types of illness.

This site also provides information on the placebo effect, which, although mostly ignored or ridiculed, is actually a very powerful healing force and appears to operate through the HPA axis.

This website was developed by David Jameson, a recovered CFS/ME patient who has been symptom free for over 14 years (as of 2015). Please let me know if you find the information on this website useful, or if you have any comments.

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